In view of the imbalance between the current business environment and regional economic development, based on the coupling theory, taking 14 cities in Liaoning Province as the analysis object to, the coupling coordination degree model of the business environment and regional economic growth are constructed from 2012 to 2019 and empirical analysis is made. The results show that the coupling coordination degree between business environment and economic growth in Liaoning province increases slowly, and there are differences in coupling coordination between cities. With the rapid economic development of Liaoning Province, the business environment lags behind the economic development, so optimizing the business environment is the key to promote the local economic development.