Route is the basis for airlines to obtain revenue. Evaluating route is a necessary step for airlines. In order to quantitatively evaluate the route benefits and comprehensively consider the cost and income, the initial evaluation index is established. There are many factors affecting the route evaluation. The evaluation index is selected, and the evaluation index system in five aspects is established,including passenger occupancy rate, competitive operation conditions, the impact of route network, market demand and cost fare ratio. For the multi-attribute route evaluation decision, the route is evaluated by TOPSIS method, and the attribute index is determined by entropy weight method. Then, the route is evaluated and sorted by judging the fit between the route selection and the ideal solution using TOPSIS method, so as to select a better route. Finally, the route of Harbin airport is evaluated. The results show that TOPSIS method can quantify the optimal route of airlines in different situations, which is consistent with the actual situation. The final result proves the effectiveness and feasibility of the evaluation method. A route evaluation method is provided when the attribute weight is unknown, which has certain guiding significance for other airlines.