Using the linear weighting method, the grey relational entropy model and the dissipative structure theory, based on the rationalization of industrial structure and the advanced theory of industrial structure, the development status of regional digital economy, the status quo of industrial structure and the impact of regional digital economic development on industrial structure in recent years are studies. Through the calculation of relevant indicators, it is concluded that the level of my country's regional digital economy shows a trend of continuous growth, but there are differences between different regions. The digital economy level of the eastern provinces is better than that of western provinces. The results of grey relational entropy model and dissipative structure theory show that digital economy can significantly promote the optimization and upgrading of regional industrial structure.