Based on the sample data of 172 wellness tourism destinations in Shanxi Province,the spatial distribution characteristics, equilibrium degree and influencing factors of wellness tourism destinations is explored with the help of spatial analysis tools such as the average nearest neighbor index, kernel density and mathematical models such as geographic concentration index and Gini coefficient. It is found that wellness tourism destinations present an L-shaped spatial structure of “large dispersion and small agglomeration”.There are significant differences in the quantitative characteristics, spatial structure and influencing factors of different types of wellness tourism destinations.Natural resource endowment establishes the basic pattern of “dense in the south and sparse in the north", and transportation conditions play a guiding role. Therefore, some suggestions for optimization were put forward,including based on the core circle axis to radiate and drive other areas to build a new pattern of wellness tourism in the whole province.All cities give play to their characteristic advantages to achieve regional differentiation and branding of wellness tourism.Strengthen the optimization and integration of regional resources and promote the innovative and interconnected development of wellness tourism destinations.