Aiming at the complexity of normalized epidemic prevention and control in Colleges and Universities,a dynamic evolutionary game model between colleges and students is established and the stable evolution strategies and influencing factors of both sides in different situations is analyzed .The research shows that the negative prevention and control loss, punishment amount, prevention and control cost and supervision efficiency of colleges and universities, the opportunity cost of students, rewards and fines will guide the stable evolution strategies of both sides, which tend to be strict prevention and control of colleges and universities and active cooperation of students, so as to quickly and effectively prevent the spread of the epidemic.