With the implementation of innovation-driven development strategy, a number of regional innovation highlands have emerged. However, the regional coordination of innovation and development is still insufficient, and there are large gaps between different regions. In order to explore the specific reasons for the gap between regions, relevant data is used to evaluate the symbiosis level of industrial innovation ecosystem in different regions of China, and the methods of linear regression and ridge regression is used to analyze the mechanism of symbiosis unit, symbiosis matrix, symbiosis platform, symbiosis network and symbiosis environment affecting regional industrial innovation ability. The results show that symbiosis unit, symbiosis environment and symbiosis network have more prominent influence on regional industrial innovation capability than symbiosis matrix and symbiosis platform, and draw policy suggestions: compared with attaching importance to innovation investment and innovation platform construction, cultivating innovation subjects, improving innovation environment and promoting innovation cooperation should also be paid more attention. This will help to promote the continuous improvement of regional innovation capacity and the coordinated development of regional innovation pattern.