Using China's direct investment data for eight important investment countries from 2010 to 2019 as the panel data, based on the gravity model, the index of economic policy uncertainty as an explanatory variable is introduced to explore the impact of economic policy uncertainty on OFDI in China. The results show that the economic policy uncertainty of the host country will restrain the investment of the home country, while the economic policy uncertainty of the home country will promote the FDI of the home country. Finally, based on the results of the modeling, the corresponding suggestions for the home country of investment are put forward.