The Yangtze River Delta has become a leading area for the development of headquarters economy in China, and the headquarters economy is gradually becoming an important form of high-quality economic development in this region. In the context of the integrated development strategy of the Yangtze River Delta, to achieve the coordinated development of regional headquarters economy and solve the problem of the abuse of headquarters resources between cities, the key is to explore a headquarters economic development path that will be suitable for small and medium-sized cities in the Yangtze River Delta region. Taking Jiaxing City as an example, the status quo and challenges of the headquarters economy in Jiaxing is analyzed, and the main requirements of the enterprise development of Jiaxing’s headquarters is sorted out through field research. Based on this, the basic positioning and path selection for the development of headquarters economy in small and medium cities in the Yangtze River Delta, as well as specific policy recommendations to promote the development of headquarters economy in Jiaxing are put forward.