An evaluation system of digital transformation development of regional manufacturing industry is constructed based on the three elements of digital infrastructure, digital industrialization and industrial digitalization of digital economy． The level of digital transformation of manufacturing industry in representative provinces of China from 2017 to 2019 is measured by entropy weight method, and the comparative analysis is made．The results show that：There was an obvious gap in the development of regional manufacturing digital transformation in China．There are some problems in the digital transformation process of manufacturing industry in Yunnan Province，such as the weak supporting capacity of digital infrastructure，the lower level of industrial digital transformation，the weak degree of coordination of industrial chain digital transformation，and the shortage of science and technology and human resources. The countermeasures to improve the level of digital transformation of manufacturing industry in Yunnan Province with significant regional characteristics are put forward．