Based on the research of 28 subdivided manufacturing industries in five provinces of the Central Plains Economic Zone, the industrial linkage degree of 28 subdivided manufacturing industries in five provinces is analyzed using a variety of quantitative analysis tools and methods such as industrial structure similarity coefficient, location entropy, industrial competition and cooperation index and industrial linkage degree model.The results show that within the five provinces, the overall differences of different regions and industrial development levels first expand and then shrink, while the relative differences of industrial development levels continue to shrink. The phenomenon of industrial isomorphism is more prominent among the five provinces. On the whole, the industrial linkage in the Central Plains Economic Zone is mostly concentrated in low value-added industries, while the interaction in emerging industries is less.