Rural e-commerce is one of the important ways for the country to support agriculture and rural areas. Excepting improving farmers' income, it can also improve the rural employment rate, which is of great significance to rural development.The fuzzy set qualitative comparative analysis (fsQCA) method was used to explore the retention intention of rural e-commerce entrepreneurs in Turpan City, and to explore the promotion path of rural e-commerce entrepreneurs' retention intention under the condition of multiple factors and multiple interactions.The results show that among the five factors including, infrastructure, government service, social factor, resource endowment and market environment, single factor can not constitute the necessary conditions to affect the results,but play a role through the combination of conditions.Finally, four combination paths with strong retention intention were obtained, namely “INF*SOC*RES*~MAR”type,“INF*GOV*SOC*RES*MA”type,“INF*～GOV*～SOC*RES*MA”type and“~INF*~GOV*SOC*RES*MAR”type.The influencing factors of rural e-commerce entrepreneurs' work intention to stay are complex and multi-dimensional.It is of great practical significance to choose targeted combination paths to motivate rural e-commerce entrepreneurs and improve their work intention to stay.