Based on the DEA-Malmquist model, the scientific and technological financial efficiency of 18 cities in Henan Province from 2010 to 2019 was measured.The results show that the efficiency of science and technology finance in Henan Province is generally in the weak and effective state of DEA and the efficiency of science and technology finance in various regions shows obvious regional unbalanced development trend. The combined efficiency mean of science and technology finance in other cities ranged from 0.344 to 0.963, but the operational efficiency level of science and technology finance in two-thirds of the cities has improved. According to the empirical results, some suggestions are put forward from the aspects of rational allocation of scientific and technological financial resources, strengthening the construction of scientific and technological innovation personnel and expanding the scale of high-tech industries.