Using the game model, the unstable factors of cooperation among enterprises in cold chain logistics is discussed , and how blockchain technology that ensures the stable operation of cold chain logistics is analyzed. The research shows that the stable operation of the cold chain logistics link is constrained by the market. By improving the information opacity in the cold chain logistics, the blockchain technology realizes decentralization and the data on the chain can not be tampered with, and its technical characteristics are used to ensure the stable operation, coordination and cooperation of enterprises on the cold chain logistics chain, so as to finally realize the stable cooperation and income of participants in the whole link.