Liquid nano-silica anti-channeling cement slurry system is widely applied by Sinopec recent years. The key properties of the slurry system in the presence of fluid, plastic and solid state are systematically studied . Experiments show that, the liquid nano-silica particle size is small and the specific surface area is large. The cement slurry system has better basic properties than the ordinary cement slurry system in the presence of flow state, such as, power-law index 0.69, consistency coefficient 0.45 Pa·sn, API water loss 36 mL, no free liquid, no sedimentation. Blocking and procoagulant effect of nano liquid-silica particles can improve anti-channeling performance of cement slurry system during plastic transformation. The SPN value of gas channeling factor is 1.3, which is 62.9 % lower than that of ordinary cement slurry system. The time of static gel strength developing from 48 Pa to 240 Pa is 7 min. There is no channeling phenomenon in the simulation experiment. Liquid nano-silica particles can increase the compactness of cement stone, and repair the internal micro cracks and micro defects of cement stone by participating in cement hydration reaction. The mechanical properties of solid cement stone are also significantly better than ordinary cement stone. When the dosage of liquid nano silica is 15 % and the age is 7 d, the elastic modulus of cement is 8.3 GPa, the decrease is 38.9 %, the strength of cement is 53 MPa, the increase is 35.9 %, and the permeability is 0.007 ×10-3μm2, which is 90.9 % lower than that of ordinary cement. Nanoparticles have the role of limiting support. The nano-liquid silicon cement slurry system has lower hydration shrinkage after being transformed into plastic and solid. The plastic state shrinkage and solid state shrinkage are 1.26%, 0.34% lower than that of ordinary cement slurry. Finally, the application of liquid nano-silica cement slurry system in Shunbei Oilfield is introduced. The cumulative application of more than 150 wells, the average cementing excellent rate is 91.7 %, which mainly solves the channeling problem of Sangtamu high pressure water layer and diabase salt water layer in production casing cementing.