Small and medium-sized enterprises (SMEs) are the most activity part in national economy development, and scientific and technical innovative ability of SMEs are closely related the national activity and ability in technology innovation field. Taking CiteSpace software and biliometrics method, China’s SMEs technology innovation research hotspot, and tendency in recent 10 years was analyzed to conclude the barriers and problems of China’s SMEs development in technology innovation while provide suggestions. The research results show that the research hotspot focus on the economy environment establishment, innovation human resource, innovation policies, financial support and collaboration mechanism creation, and the tendency turns from the outline and framework research into the inner problem research, such as SME management, creative mechanism and human resource management and other inner driven power research. Briefly, in order to improve technology innovation ability of SMEs in China , the collaboration and integration among policies environment, multi-financial services system and effective S&T cooperation mechanism was needed.