Based on the perspective of cluster analysis, the tobacco sales data of Hubei Province and other provinces with similar economic development level were analyzed，to analyze the regulation of tobacco products in Hubei Province. It was concluded that there was little difference in the distribution of tobacco products in Hubei Province, Henan Province and Hunan Province. Some processing can be done between the four to eight grades of tobacco product design, and it is improved the quantity of five and eight grades of tobacco. At the same time, the level of economic development in Hubei Province will significantly affect the product design distribution of tobacco in Hubei Province in the future, and relevant suggestions are given based on this.