To solve the problems in the development and construction of the industrial chain, the stubborn diseases that impede the upgrading of the industrial chain is analyzed. On the basis of exploring the internal relationship between industry, university and research, industrial agglomeration, and industrial chain upgrading, the path and method of industrial chain upgrading are studied, and a new model for the establishment of an industrial innovation center is proposed. The construction of industrial innovation center and its construction effect are analyzed, and countermeasures and suggestions are put forward . Studying the upgrade path of the industrial chain and analysis of platform construction is helpful to promote the deep integration of the innovation chain and the industrial chain, accelerate the flow of innovative elements, promote the advantage of the industrial chain and overcome disadvantages of the industrial chain, finally help the industrial chain upgrade.