After describing the temporal and spatial evolution of industrial wastewater, waste gas and smoke (powder) dust emissions in Wuxi from 2001 to 2020, the influencing factors are analyzed by LMDI model. The results show that during the sample period, the emission of industrial wastewater and smoke (powder) dust decreases as a whole, and the emission of waste gas increased several times. At present, there are relatively more pollution emissions in urban areas and Jiangyin, especially wastewater and waste gas. Economic scale leads to the increase of industrial pollution emissions, the reduction of industrial structure, and the action direction of technical level is different, and there are obvious differences in the action degree of the three factors on different kinds of pollution. In terms of regions, the urban area and Jiangyin contribute greatly to the change of industrial pollution emissions. The increase and decrease direction and driving factors (factor contribution and regional contribution) of pollution emissions of different varieties are also different in the four periods.