The science and technology service industry is an important driving force to promote the optimization and upgrading of the industrial structure. Establishing a mature system and mechanism for the science and technology service industry is an important way for the stable development of the science and technology service industry, which can promote the effective development of enterprise innovation activities, and improve the rapid upgrading of the local economy. At present, China's economic growth is in a critical period of slowing growth and difficult transition. Analyzing the innovation development efficiency and development path of the technology service industry can provide decision-making reference for regional economic restructuring, industrial layout and related policy making. This research is based on the input-output elements of the science and technology service industry in Changzhou in the past ten years, using data envelopment analysis (DEA) to analyze and study the innovation efficiency of the science and technology service industry in Changzhou in the past ten years. It compares the level positioning of Changzhou's science and technology service industry in the average development of the five cities in southern Jiangsu and Jiangsu Province.