The degree of low-end lock of Guangxi manufacturing industry is measured based on the two dimensions of the final demand distance index and the technical structure. It is found that the final demand distance index of Guangxi manufacturing industry is extremely small and has not shown a significant growth trend, facing a deeper level of low-end lock. Manufacturing industries of different technology categories faces significant heterogeneity in the level of low-end lock. The degree of low-end lock of high-tech manufacturing industries is higher than medium-tech manufacturing industry. The low-end technology structure further deepens the degree of low-end lock of Guangxi manufacturing industry. The low-end lock degree of Guangxi manufacturing industry is higher than that of Sichuan, Chongqing, and Shaanxi, and the number of industries whose competitiveness has continued to improve is relatively small. The planning and construction of the "Dual Science and Innovation Corridor", the implementation of a differentiated unlocking strategy, and the construction of a demonstration zone for undertaking intangible intellectual resources are important ways to unlock the low-end lock of Guangxi manufacturing industry.