Based on the input-output method, makes an empirical analysis of tourism development from the perspectives of regional space and industrial economy, aiming to explore "tourism space network" and "tourism industry network". From the perspective of space, tourism is a comprehensive industry that links the economic growth of cities, towns, villages and scenic spots. In terms of regional space, it forms a spatial network structure from "point" of tourist city to "line" and "network" of tourist route. From the perspective of industry, tourism is a “yeast like” industry that drives economic development. In terms of industrial structure, it creates a network of industrial economy with a core composed by six elements: food, housing, transportation, tourism, shopping and entertainment, and nearly one hundred of industries interacting with each other". Taking Yunnan Province as an example, the transformation and upgrading of Tourism Industry in Yunnan was studied.While Yunnan tourism is undergoing transformation and upgrade, some difficulties still exist, including the first stop as the business card is not impressive, core Intellectual Property (IP) of characteristic towns is weak, driving force from "travel" and "purchase" is insufficient, and not very smooth network key nodes or disconnected network, etc. Combined with the economic characteristics of the tourism network industry and oriented to the development difficulties, this paper makes some strategic policy suggestions such as reinforcing the impression of the first stop, increasing creativity of core IP, transforming the tourism mode, and improving the efficiency of tourism. We hope that Yunnan can accelerate in building a better world-class tourist destination.