Panel data of provincial regions in Mainland China from 2008 to 2019 is used to study the impact of scientific and technological human resources on labor income share from multiple dimensions. The results show that the S&T human resource changes in the same direction with labor income share in the eastern region, and in the central and western regions, it changes in the opposite direction with labor income share. High-tech hr region has a significant positive impact on labor income share, while low-tech HR region has a significant negative impact on labor income share. On the basis of ensuring the robustness of the research conclusions, corresponding suggestions are put forward.