Based on the data of employees, the urban functional division of Huaihai economic zone is analyzed from 2006 to 2018 by using location entropy, and the evolution characteristics is summarized. The results show that: The employment capacity of Huaihai Economic Zone continued to increase from 2006 to 2015, and then decreased in 2018. Manufacturing, other industries and other service industries dominated, advanced producer services and general producer services developed slowly, and the overall industry is still in the middle and lower reaches of the value chain.The industrial layout presents a state of differentiation, but the degree of specialization is weakening, and the transformation of the main advantage industrial structure is difficult. Finally, from the three aspects of central city, regional cooperation and industrial structure, this paper puts forward policy suggestions for the coordinated development of industries in Huaihai economic zone.