The tendency?of the industrialization of modern biotechnology plays an important role in promoting the process of sustainable economic and social development, such as medicine, agriculture, energy, materials, chemical industry and environmental protection. It has become a focus of today's international competition of science and technology. The overall level of China's biotechnology industry is in the middle and low end of the industrial value chain. This paper analyzes, synthesizes and compares the industrial application of modern biotechnology in Shandong by using the methods of comparison, example and investigation, analyzes the problems in the industrialization application of biotechnology,and puts forward countermeasures and suggestions to promote the industrialization application of biotechnology from the strength of policy incentives, financing, build efficient modern biological technology innovation chain and so on.