Industry transfer and regional innovation exists inherent coupling coordination requirements. Building the evaluation index system on the basis of coordination mechanism,and adopted the entropy method and using the coupling-coordination degree model to 2009-2019 in Guangzhou metropolitan area of industrial transfer system and the comprehensive level of regional innovation system and coupling coordination degree of calculation and analysis, and explore the industry transfer from the angle of time and space and the coupling coordination development trend of regional innovation. Research shows that in the industrial transfer policy implementation and perfecting regional innovation system, under the condition of Guangzhou metropolitan area the comprehensive level of industrial transfer and the regional innovation system and coupling coordination degree are the overall upward trend, and coordination type also start from low level to moderate levels, but still have considerable difference area. In view of the above findings, some policy development suggestions are given.