Taking the Yarra River Bridge of Sichuan-Tibet Railway as the research object, reasonable seismic fortification measures for high-seismic near faults zone is studied.Using the relative displacement of the pier-beam as the control index, the velocity-based and displacement-based damper measures of different tonnage levels are compared, and appropriate mechanical parameters of the damper are preliminarily formulated. Furthermore, through comparing the performance indexes of bridge piers, pile foundations, bearings and main beams in the case of different seismic isolation schemes, a reasonable seismic isolation scheme is obtained.The research shows that: The velocity-based dampers with the same tonnage have better performance both in displacement limiting and internal force isolation. The velocity response of the damper in transverse bridge directions is lower than that of longitudinal direction. And, the 120 t yield force displacement-based damper has achieved the same seismic isolation effect as the velocity-based damper with the 100 t damping force.