The situation of production safety of China's machinery manufacturing enterprises is still grim at present. The construction of a feasible and effective emergency management mechanism, the prevention and response of production safety accidents in machinery manufacturing enterprises has become an urgent problem. According to the characteristics of emergency management in machinery manufacturing enterprises, the emergency management mechanism is established based on the double prevention mechanism, the long-term mechanism of enterprise risk control and accident prevention is established through the three links of pre prevention, accident response and post-processing.The research shows that: strictly implement the construction work of double prevention mechanism, firmly build the safety door of accident prevention, in the most economical and effective way, force the improvement of safety production management level, control the risk, clear the hidden danger, achieve no emergency response, emergency response, immediately respond to the alarm, and quickly recover, plays an important role in the prevention and control of accidents in machinery manufacturing enterprises.