Discusses the scientific setting of passenger guidance signs in hub airports. In order to solve the problem of setting the space position of the passenger-oriented sign, this paper establishes a key node selection optimization model, uses mathematical models to solve practical problems, and uses LINGO software to calculate and solve.Taking T3 Terminal of Shenzhen Baoan International Airport as an example, analyzes the existing problems of the guide-sign and puts forward suggestions for optimization and improvement, so as to make the guide-sign more scientific, reasonable, convenient and efficient.