Structural blast-resistant design of buildings are discussed from the aspects of explosion load, structural and material type, analysis methods, and design procedure according to the relevant provisions of ASCE41088 and GB50799. Structure designs of the converter station on the petrochemical artificial island of a flexible direct-current transmission project in a foreign country are taken as the background. GIS power distribution equipment room typical in the flexible direct-current converter station are taken as an example to carry out the blast-resistant design and check of single-layer portal frame structure. The separate equivalent single degree of freedom system analysis and multiple degrees of freedom system for the dynamic analysis method are adopted. The results show that the ductile structure system that designed reasonably can generally meet the blast-resistant requirements under far-distance and long-duration blast loads. The research can give reference for the structural blast-resistant design of similar projects at home and abroad.