For domestic small and medium-sized airport layout is increasingly perfect, the lack of quantitative problems, open up new routes to choose from the perspective of the airport,combined with passenger demand of potential indicators and connectivity index and empty tin competition index build hybrid index selection model, to study the opening of new routes selection problem of small and medium-sized airport, provide quantitative reference basis for the airport in route choice. Through the study of the example of sunshine airport as the research object, the passenger throughput of 1.2 million, 3 years is expected to design of airport departure flights to 79 500 times, route subsidies for 1 million planning requirements, plans to open six routes, using mixed index selection model of route choice, the six of the optimal route, a planning requirements. The example proves that the model is feasible in route development and provides reference for the selection of airport route development.