It is imperative to promote the internal economic cycle and promote the high-quality development of the regional economy. Based on the existing research on regional economic development in my country, from the five dimensions of stability, innovation, coordination, greenness and sharing of economic development, constructed an evaluation model and indicator system for high-quality economic development in Shenzhen, Guangzhou, Dongguan and Foshan. Based on the thermodynamic evaluation model, the regional economic quality development evaluation model of the Guangdong-Hong Kong-Macao Greater Bay Area was constructed, and the economic development of the four major cities was evaluated, analyzed and ranked, to verify the feasibility of the model in this paper, and to improve the high-quality development of the Greater Bay Area.