Based on the reality of Henan Province’s high-quality development, constructs a high-quality development index system in Henan Province from three dimensions including economy, ecology, and society. It uses principal component analysis to measure the high-quality development level of 18 cities in high-quality and explore its influencing factors. The research results show that the High quality high level of development areas are mainly concentrated in zhengzhou and the surrounding area, moderate area city, most low area mainly located in southern henan eastern edge of the area and so on, the overall development level is low and the high quality imbalance, the main influence factors is the development of economy and the environment coordination degree is not enough, social livelihood of the people level still need to continue to improve.