The incidence of people buried in grain dumps is high, and the rate of survivors is low. In order to study the causation of accidents and preventive measures, 46 accidents involving people buried in grain piles were analyzed using the "2-4" model. First, the direct and indirect causation of the accident were analyzed from the individual level. Second, the basical causation and root causation of the accident were analyzed from the organizational level. Finally, the causation chain of the accident of the people buried in the grain pile and propose preventive measures were build. The results show that unsafety actions such as working on the surface of unstable grain piles, inadequate safety training, and unsafety physical conditions such as unreasonable design of the grain board are the direct causations of the accident; insufficient safety knowledge, low safety awareness, and poor safety habits are the indirect causation of the accident; the lack of safety inspection system, outsourcing management system, safety facilities, equipment management system, arching, and the lack of operation procedures to deal with arching and wall-mounting, and the lack of grain storage operations procedures are the root causes of accidents; the root causation of accident is the lack of safety culture.