Research on the relationship between civil aviation transportation and regional economy can promote the sustainable development of both civil aviation transportation and regional economy, and achieve the mutual benefit. In this paper, the relevant index data of Sichuan civil aviation transportation and regional economy from 2004 to 2018 are standardized and analyzed by coupling and coordination degree model. Then the coupling and coordination degree of Sichuan civil aviation transportation and regional economy in this period is obtained. The results show that the overall coupling and coordination of them is well in this period, and the regional economic development lags slightly behind the civil aviation transportation. It is predicted that the pulling effect of civil aviation transportation on regional economy will continue to increase in the future.