Promoting the transformation of scientific and technological achievements is an important content and task to promote the implementation of innovation-driven development strategy, and an important means and path to promote the close combination of science, technology and economy. By combing the practices and achievements of the transformation of scientific and technological achievements in Anhui Province, this paper analyses the problems and challenges of the transformation of scientific and technological achievements, and puts forward some pertinent and operable countermeasures and suggestions for speeding up the transformation of scientific and technological achievements in Anhui Province.