Based on the analysis of the connotation of high-quality development, the evaluation index system of high-quality development level in Guangxi, including 30 indicators, was constructed from six aspects: high-quality economy, innovative quality, coordinated quality, green quality, open quality and Shared quality. The entropy method was used to determine the weight, and the comprehensive score of high-quality development level of 14 prefecture-level cities in guangxi from 2008 to 2017 and the average score of 10 years were comprehensively calculated. From two angles of time and space difference analysis of Guangxi development of high quality, comprehensive analysis shows that Nanning City and Guilin City have high quality development level, and Liuzhou City, Chongzuo City, Qinzhou City, Beihai City, Fangchenggang City and Yulin City have medium-quality development level, Guigang City, Wuzhou City, Hechi City, Hezhou City, Baise City and Laibin City was general; finally, according to the analysis results, 14 high-quality development suggestions were proposed for 14 prefecture-level cities.