Scientific and technological innovation is the driving force of regional economic development. Based on the panel data of 31 provinces and cities in 2014-2018, the PCSE regression model is constructed to empirically analyze the relationship between scientific and technological innovation input and output and economic development. The results show that the investment in scientific research and the output of high-tech industries in the domestic market have a positive effect on economic development, and the sales effect of scientific researchers and new products put into production in the domestic market is not significant. In view of this, under the current technological innovation and the new economic normal, attract high-quality talents, improve the quality output of scientific and technological innovation, and at the same time promote the development of high-tech industries, implement scientific research into basic products, and promote coordinated economic development.