Synergistic development plays an important role in promoting the regional innovation capability and economic development of Beijing-Tianjin-Hebei region. This paper constructs a cross-regional collaborative innovation framework for industry, university and research from the perspective of synergy, and combines the relevant data of Beijing-Tianjin-Hebei 2002-2016, based on the composite system synergy model, empirically analyzes the synergy degree of the Beijing-Tianjin-Hebei industry-university research innovation system.The results show that:①Beijing production The research and innovation innovation subsystem has the highest degree of order, the internal synergy is the strongest, followed by Tianjin, Hebei has the lowest degree of ordering.②The synergy degree of the production, research and research innovation composite system in all sub-regions of Beijing-Tianjin-Hebei has reached a good level of synergy.③The cooperation between the research institutes and the research institutes in the sub-regions of Beijing-Tianjin-Hebei sub-regional research and development--the cooperation of the university subsystems is higher than that of enterprises-scientific research institutions and enterprises--colleges, and the cooperation between enterprises and universities and scientific research institutions needs to be further strengthened.④The overall level of synergy between the industry, academia and research institutes in the Beijing-Tianjin-Hebei region is low and fluctuating. Finally, based on the conclusions, this paper proposes to promote the coordinated development of industry, university and research in Beijing-Tianjin-Hebei region, and provides ideas for constructing a new pattern of synergy development between Beijing, Tianjin and Hebei.