Take the S&T service demand of small and medium-sized enterprises in Ningxia as the research object，analyzes the service demand of six aspects，such as research and development，technology transfer service，etc. At the same time，it also analyzes the current scientific and technological service development level and the importance，draws a basic conclusion that the demand for S&T service of small and medium-sized enterprises in Ningxia is generally strong，the types of S&T service are various，and the satisfaction of S&T service level in the region is general. It also puts forward that the small and medium-sized enterprises should be guided to carry out R&D activities step by step，strengthening the specialized service of small and medium-sized enterprises and innovating the way of government management，in order to provide reference for Ningxia to better carry out science and technology service activities.