The International Air Logistics Center(IALC) has increasingly become a strong driving force and an important functional carrying area for regional economic development, national opening up and international trade. Investigated and summarized the development status and successful experience of IALC at home and abroad, combined relevant literature and expert consultation to obtain the influencing factors and index systems of IALC development, and finally got their internal structure by using ISM. The hierarchical structure of the influencing factor indicators is, from the bottom up, the deep influencing layer, industrial support and basic supporting system layers, software and hardware infrastructure, business service layer, operational cost control layer and air channel construction layer. The bottom layer of factors has an impact and drive on the factors at the up ones. Through factor analysis, the key factors and factors of the development of IALC are clarified, which provides theoretical guidance for better promoting the development of IALC.