The development of small and medium-sized enterprises is an important force for regional economic growth. Based on the entropy weighting method, the statistical data of 36 small and medium-sized enterprises were selected, and the financing ability of small and medium-sized enterprises in Lanzhou was evaluated. The results show that the main factors that affect the financing ability of enterprises are the profitability of enterprises and the basic situation of enterprises. Lanzhou non-listed science and technology small and medium-sized enterprises financing ability is lagging behind the new three-board listed enterprises, also lagged behind the national non-listed enterprises, financing capacity is poor. Finally put forward the relevant countermeasures and suggestions, better solve the problem of corporate finance, promote enterprise development.