Starting from the creative city, the index system is constructed from the perspective of innovative subjects involved in innovation diffusion activities, using the improved model of CH to study on the innovation diffusion effects. Based on relevant data of Nanjing from 2001 to 2015, empirical study on the innovation diffusion effects in Nanjing. Results showing: R&D investment and technology trading have a significant positive effect on the TFP of Nanjing; science and technology of government expenditure has a weaker positive effect; R&D personnel has a significant reverse effect. Scientific and technological loans of financial institutions and FDI have no significant impact on the innovation diffusion effects of Nanjing. Based on the empirical results, policy recommendations are put forward.