This paper uses improved game cross efficiency model to calculate the game results of industry innovation performance in China 30 provinces during 2012-2015.The study finds:innovation performance of industrial enterprises in China is overall in the middle level, and shows the "V" trend that rises after the first drop. Regional differences in innovation performance of industrial enterprises in China is obvious. On the whole, the innovation performance of regional industrial enterprises shows the gradient trend of "high in the East, low in the West and central in the middle". From the years of view, the eastern region shows a sustained decline and then a strong recovery trend, the central region shows a wave of high and low volatility trend, the western region shows?downward?trend and then slow recovery. Differences of industrial enterprises innovation performance between each region tend to converge. The regional utilization patterns of industrial enterprises innovation performance can be divided into 6 categories. According to its characteristics,each province should adopt different strategies to improve the level of innovation performance of industrial enterprises.