As an essential part of the national economy and as the pillar of the third industry, cultural and creative industries play key roles in the economic development. Yet, the Internet has created huge challenges to the cultural and creative industries which take the copyright as the core. Facing the issue of copyright protection, local cultural and creative industries have been in the“prisoner's dilemma”, which brings losses to the industries. Based on the static game model, this paper makes game analysis of the relationship of the cultural creative enterprises from the prospective of copyright protection. The study shows cultural and creative works can be protected by cracking down on?piracy severely. In addition, high social reputation has a positive influence on copyright protection of cultural and creative industries. Some recommendations related are made on the copyright protection of cultural and creative industries finally.