Using the software of GeoDa and ArcGIS, this paper selects 11 counties that can reflect the development of county economy in Anhui Province in Anhui Province in 2000 and 2014, and establish the county level economic development level in Anhui Province Comprehensive evaluation index system. The economic development level of 61 counties in Anhui province was measured by the entropy method. The characteristics of the economic development and the spatiotemporal evolution law of Anhui province were analyzed by ESDA method. The results show that:①There is still a big gap in the development of county economy in Anhui Province.②From 2000 to 2014,the development level of county economy in Anhui Province became more balanced.③The future economic development of Anhui Province should be in the "multi-axis - multi-core" point-axis spatial structure development.