The 2005-2014 GDP per capita as an indicator variables，Using range, standard deviation (absolute difference) and ratio of extreme value, variation coefficient (relative difference) to analyze the evolution trend of the county economic development in the eastern region of Qinghai province. Select 9 indicators of each county in 2014 to build the evaluation index system of county economic development strength，Using the principal component analysis and GIS methods to analyze various counties economic space difference .The main findings are shown as follows: In the past ten years, the overall difference between counties in the eastern part of Qinghai province is expanding, further aggravate the imbalance between regions, although in recent years to further narrow the differences, but compared with previous years, the overall difference is larger; To establish a comprehensive evaluation model, according to the comprehensive score of counties can be divided into the quite developed type, Less developed type and undeveloped type three kinds of regional types. Huzhu County, Datong County comprehensive score higher in the seven counties in the economic comprehensive strength of strong. The comprehensive score of Huangzhong county and Minhe county is located in the middle, so it is less developed. Xunhua County, Hualong county and Huangyuan County comprehensive score is negative, which shows that the development level is located under the average, so it is undeveloped type.