Taking 144 counties level as the study of space scales on the western coast of Taiwan straits, choosing the bigger influence on economic development level index such as per capita GDP, using factor analysis method to determine indexes weight and then combine with ESDA to analysis difference of the county development.The results show that the county economic development in the western coast of Taiwan straits has strong correlation, the global spatial distribution of the spatial distribution has significant agglomeration effects, but uneven distribution in provincial and local spatial autocorrelation in some counties, which the Wenzhou area as the center of appear H - H type concentration, Zhejiang province, Jiangxi province and Guangdong province part of counties surrounding about Fujian province belong to L - L type concentration, Suggestions according to the core-periphery theory as the center of Fujian province to promote the economic development of the other counties.