Promoting the integration of innovation chain, industrial chain, service chain and capital chain is the effective way of accelerating the combination of technology and economy and optimizing the allocation of scientific and technological resources. Through the comparison and analysis of the experience and practice of Silicon Valley in the United States, TAEDOK Science Park and China's Shanghai, Sichuan and Shanxi, identified the key success factors and the similarities and differences of success of these regions. Summed up five fusion rules of four chain and put forward five suggestions, for reference.