According to the characteristics of high- tech industry and industrial competitiveness theory, from the capability of industrial input, technological achievement transformation and industrial output to construct the evaluation index system to comprehensive evaluation and analysis on the competitiveness of high-tech industry in 31 provinces and cities by using the method of factor analysis. The results show that Henan high- tech industrial competitiveness at the middle level, and its input’s capability is prominent, and the competitiveness of the output is less pronounced. As far as six provinces in the central region, Henan high-tech industry competitiveness ranked second, with a relatively strong competitiveness, which plays an important role to promote the development of central provinces.