Comprehensive evaluating indicator system for the commercialization of research findings is conducted. DEA-BP neural network comprehensive evaluating model is presented combined data envelopment analysis (DEA) with BP neural network. This paper conducts empirical research for enterprises above the designated size of Shanghai from 1998 year to 2009 year with the DEA-BP neural network model. Simulations and results validate its efficiency and superiority of DEA-BP neural network model, and some suggestions for improving the efficiency of commercialization of research findings are put forward based on the model.